Fernand-Pierre Gendron, PhD

Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz  H, Sévigny J, Fischer B. Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P(α,α)-Dithiophosphate Analogues. J Med Chem. 61(9):3939-3951, 2018.  

Placet M, Arguin G, Molle CM, Babeu JP, Jones C, Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP. The G protein-coupled P2Y₆receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis. Biochim Biophys Acta. 1864(5 Pt A):1539-1551, 2018. 

Gendron FP, Placet M, Arguin G. P2Y(2) Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer. Adv Exp Med Biol. 1051: 91-106, 2017.

Arguin G, Bourzac JF, Placet M, Molle CM, Paquette M, Beaudoin JF, Rousseau JA, Lecomte R, Plourde M, Gendron FP. The loss of P2X7 receptor expression leads  to increase intestinal glucose transit and hepatic steatosis. Sci Rep. 7(1):12917, 2017.

Lepage D, Bélanger É, Jones C, Tremblay S, Allaire JM, Bruneau J, Asselin C,  Perreault N, Menendez A, Gendron FP, Boudreau F. Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Sci Rep. 6: 36776, 2016.

Bilodeau MS, Arguin G, Gendron FP. C/EBPβregulates P2X7 receptor expression in response to glucose challenge in intestinal epithelial cells. Biochem Cell Biol. 93(1): 38-46, 2015. 

Marcil V, Amre D, Seidman EG, Boudreau F, Gendron FP, Ménard D, Beaulieu JF, Sinnett D, Lambert M, Levy E. Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth. PLoS One. 10(2): e0117238, 2015.

Meltzer D, Ethan O, Arguin G, Nadel Y, Danino O, Lecka J, Sévigny J, Gendron FP, Fischer B. Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists. Bioorg Med Chem. 23(17): 5764-73, 2015.  

Vinette V, Placet M, Arguin G, Gendron FP. Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs. PLoS One. 10(8): e0136080, 2015. 

Turgeon N, Gagné JM, Blais M, Gendron FP, Boudreau F, Asselin C. The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 306(7):G594-605, 2014. 

Asselin C, Gendron FP. Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis. FEBS Lett. 588(22): 4148-57, 2014. 

Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. PLoS One. 8(11):e81491, 2013.